Labcotrim (Sulfamethoxazole + Trimethoprim): Uses, Side Effects, and NAFDAC Number

What it is

Labcotrim is a combination antibiotic containing sulfamethoxazole (a sulfonamide) and trimethoprim. It works by stopping the growth of bacteria and is used to treat various bacterial infections.

What it's used for

Labcotrim is used to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. These include urinary tract infections, shigellosis (a type of bacterial diarrhoea), and acute otitis media (middle ear infection) in children. It is important to use it only when necessary to reduce the risk of antibiotic resistance.

How it's taken

Labcotrim is available as a suspension (liquid) with a strength of 200 mg/5 mL sulfamethoxazole and 40 mg/5 mL trimethoprim. It is taken by mouth. The dose and duration of treatment depend on the type of infection, the patient's age and weight, and their kidney function. Labcotrim is not recommended for infants younger than 2 months old. Always follow the dosage instructions given by a doctor or pharmacist. Do not give it to a child without a prescription.

Common side effects

The most common side effects of Labcotrim are stomach-related, such as nausea, vomiting, and loss of appetite. Skin rashes and hives (urticaria) may also occur. Rare but serious side effects include severe allergic reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis), blood disorders (e.g., agranulocytosis, aplastic anaemia), and liver damage. If you notice a severe rash, yellowing of the skin or eyes, unusual bruising or bleeding, or signs of an allergic reaction, seek medical help immediately.

Important cautions

Labcotrim should not be used by people who are allergic to sulfonamides or trimethoprim, or who have a history of drug-induced immune thrombocytopenia (low platelets from certain medicines). It is also not for patients with megaloblastic anaemia due to folate deficiency, or for infants under 2 months. Use during pregnancy may increase the risk of birth defects; inform your doctor if you are pregnant or planning to become pregnant. Labcotrim may interact with other medicines, so tell your doctor about all medications you take. Do not exceed the recommended dose.

Frequently asked questions