Spigloton: A Brand of Spironolactone for Heart Failure and Hypertension

What it is

Spigloton is a brand of spironolactone, an aldosterone antagonist. It works by blocking the hormone aldosterone, which helps to reduce fluid buildup, lower blood pressure, and improve heart function in conditions such as heart failure.

What it's used for

Based on available information, spironolactone (the active ingredient in Spigloton) is used for: treating NYHA Class III-IV heart failure with reduced ejection fraction to improve survival, manage edema, and reduce hospitalizations; as add-on therapy for hypertension to lower blood pressure and reduce the risk of strokes and heart attacks; managing edema in adults with cirrhosis that does not respond to fluid and sodium restriction; and treating primary hyperaldosteronism (overproduction of aldosterone).

How it's taken

Spigloton tablets are taken orally. The dose depends on the condition being treated. For heart failure, therapy typically starts at 25 mg once daily. For hypertension, the starting dose ranges from 25 to 100 mg daily in single or divided doses. For edema (e.g., in cirrhosis), the initial dose is usually 100 mg daily in single or divided doses, often started in a hospital. For primary hyperaldosteronism, doses range from 100 to 400 mg daily to prepare for surgery. Always follow your doctor’s instructions and do not change your dose without medical advice.

Common side effects

Common side effects include high potassium levels (hyperkalemia), low blood pressure (hypotension), worsening kidney function, breast enlargement in men (gynecomastia), electrolyte abnormalities, and neurological problems in patients with liver disease and ascites. Your doctor will monitor you for these effects.

Important cautions

Spigloton should not be used if you have high potassium levels, Addison's disease, or if you are taking eplerenone. Regular monitoring of potassium, kidney function, blood pressure, electrolytes, uric acid, and blood sugar is needed during treatment. Consult your doctor or pharmacist for a complete list of precautions.

Frequently asked questions