Doxorubicin (Doxorubicin Hydrochloride): A Guide for Patients and Pharmacists
Doxorubicin is a brand of doxorubicin hydrochloride, a chemotherapy medicine used to treat various cancers. This article covers its uses, how it is given, common side effects, and important safety information based on its NAFDAC registration in Nigeria.
- Generic: Doxorubicin hydrochloride
- Strength: 50 mg/25 mL
- Form: Concentrate for solution for infusion
- NAFDAC No.: B4-8209
What it is
Doxorubicin is a brand of the generic medicine doxorubicin hydrochloride. It belongs to a class of drugs called anthracycline topoisomerase inhibitors, which work by interfering with the growth of cancer cells. The registered product in Nigeria is a 50 mg/25 mL concentrate for solution for infusion, with NAFDAC registration number B4-8209.
What it's used for
Doxorubicin is used as part of combination chemotherapy for several types of cancer. These include adjuvant treatment for breast cancer after surgery (when cancer has spread to lymph nodes), acute lymphoblastic leukaemia, acute myeloblastic leukaemia, Hodgkin and Non-Hodgkin lymphoma, metastatic breast cancer, and various metastatic solid tumours such as Wilms' tumour, neuroblastoma, soft tissue and bone sarcomas, ovarian, bladder, thyroid, gastric, and bronchogenic cancers.
How it's taken
Doxorubicin is given as an intravenous infusion (slow injection into a vein) by a healthcare professional. The dose and treatment schedule are determined by the doctor based on the patient's body surface area and overall health. Treatment cycles are typically repeated every 21 to 28 days. Always follow the exact prescription from your doctor or pharmacist.
Common side effects
The most common side effects (occurring in more than 10% of patients) include nausea, vomiting, mouth sores, hair loss, and decreased blood cell counts (which can increase the risk of infection, anaemia, or bleeding). Other possible effects include discolouration of urine (reddish colour), fatigue, and fever.
Important cautions
Doxorubicin can cause serious and potentially life-threatening heart problems, so it is not used in patients with severe heart insufficiency or a recent heart attack. It can also cause severe bone marrow suppression, tumour lysis syndrome, and radiation skin reactions. It may harm an unborn baby; women of childbearing potential and men with partners of childbearing potential should use effective contraception. The drug must be given carefully to avoid leakage from the vein, which can damage surrounding tissue. Tell your doctor about any liver problems, as the dose may need adjustment.
Frequently asked questions
What is Doxorubicin used for?
Doxorubicin is a chemotherapy medicine used to treat many types of cancer, including breast cancer, leukaemia, lymphomas, and various solid tumours that have spread to other parts of the body.
What are the side effects of Doxorubicin?
Common side effects include nausea, vomiting, mouth sores, hair loss, and low blood cell counts. Serious side effects include heart damage, severe infection, and tissue damage if the medicine leaks from the vein.
Is Doxorubicin available in Nigeria?
Doxorubicin (as doxorubicin hydrochloride 50 mg/25 mL concentrate for infusion) is registered with NAFDAC under number B4-8209, but Drugstore.ng does not currently stock it. You can request it through the platform.
What is the generic of Doxorubicin?
The generic name of Doxorubicin is doxorubicin hydrochloride.
How is Doxorubicin given?
Doxorubicin is given as an intravenous infusion (drip) at a hospital or clinic. The dose and frequency depend on the specific cancer and patient factors, and it is always administered by a healthcare professional.
This information is for general guidance only and is not medical advice. Please consult your physician or pharmacist before using any medication.