Afrab Metformin Tablets_

.Afrab Metformin Tablets 500 mg is a prescription-only oral medication indicated for the management of type 2 diabetes mellitus. This formulation contains Metformin Hydrochloride as its active ingredient, a first-line therapy recognized globally for its efficacy and safety in controlling blood glucose levels. The product is manufactured and distributed by Afrab-Chem Limited in Nigeria.

Product Details

Active Ingredient

• Metformin Hydrochloride
• Each tablet contains 500 mg of Metformin Hydrochloride, a biguanide class hypoglycemic agent that lowers blood sugar by decreasing hepatic glucose production and improving insulin sensitivity.

Excipients

• Pregel Starch (G): 10.00 mg
• Povidon PVP (K-30): 12.00 mg
• Avicel (Microcrystalline Cellulose) PH 101: 42.50 mg
• Corn Starch: 9.00 mg
• Magnesium Stearate: 2.40 mg
• Aerosil 200: 3.00 mg
• Talcum Powder: 20.00 mg
• Sodium Starch Glycolate (Primogel): 7.00 mg

These excipients ensure the stability, integrity, and proper dissolution of the tablet.

Dosage Form and Description

• Form: Tablet
• Appearance: White, round tablet with "AFRAB" inscribed on one side and a line on the other for easy splitting and dosing.

Route of Administration (ROA)

• Oral: To be taken by mouth, usually with meals to minimize gastrointestinal side effects.

Indications and Usage

Afrab Metformin Tablets 500 mg are indicated for:

• Type 2 Diabetes Mellitus: As monotherapy or in combination with other antidiabetic agents when diet and exercise alone are insufficient to control blood glucose.
• Polycystic Ovary Syndrome (PCOS): Off-label use as advised by a healthcare provider.

Metformin is favored for its glucose-lowering effect without causing significant weight gain or hypoglycemia.

Dosage and Administration

• Recommended Dosage: Dosage should be individualized based on the patient’s needs and response, but the usual starting dose is 500 mg once or twice daily with meals. Dosage may be increased gradually to a maximum of 2000–2550 mg per day, as tolerated.
• Administration Advice: Swallow the tablet whole with water. Take with meals to reduce gastrointestinal discomfort. Do not crush or chew the tablet.

Packaging

• Pack Sizes:
• 
  
• 3 x 10’s (30 tablets)
• 10 x 10’s (100 tablets)
• Supplied in PVC-Alu blister packs for protection against moisture and contamination.

Regulatory and Product Information

• Manufacturer Name: Afrab-Chem Limited
• Product Category: Drugs
• Marketing Category: Prescription-only Medicine (POM)

Safety Information

• Contraindications:
• Do not use in patients with known hypersensitivity to metformin, severe renal or hepatic impairment, acute metabolic acidosis (including diabetic ketoacidosis), or severe infection.
• Precautions:
• Use with caution in elderly patients and those with a risk of renal dysfunction. Monitor kidney function regularly. Avoid excessive alcohol intake while on metformin.
• Possible Side Effects:
• Common side effects include gastrointestinal disturbances (nausea, vomiting, diarrhea, abdominal pain, and loss of appetite). Rare but serious: lactic acidosis, which requires immediate medical attention.
• Drug Interactions:
• Inform your healthcare provider of all medications being taken, especially other antidiabetic medicines, contrast agents, or drugs affecting renal function.

Storage Conditions

• Store below 30°C in a cool, dry place.
• Protect from moisture and direct sunlight.
• Keep out of reach of children.

Note

This article provides general product information and does not replace professional medical advice. Always consult your healthcare provider for diagnosis, individualized dosing, and management of diabetes or related conditions.