Udother Tablet 20 mg/120 mg


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Udother is a combination antimalarial medicine used to treat acute, uncomplicated malaria caused by Plasmodium falciparum. It is for patients aged 2 months and older weighing at least 5 kg.

What it is

Udother is an artemisinin-based combination therapy (ACT) containing two active ingredients: artemether and lumefantrine. It works together to kill the malaria parasite in the blood.

What it's used for

It is used to treat acute, uncomplicated malaria infections due to Plasmodium falciparum. It is not for severe or complicated malaria and is not approved for preventing malaria.

Common side effects

Common side effects include headache, loss of appetite, dizziness, weakness (asthenia), and joint pain (arthralgia). These are usually mild. Seek medical help if you experience signs of an allergic reaction (rash, itching, swelling) or irregular heartbeat.

Important cautions

Do not use Udother if you are allergic to artemether or lumefantrine. Avoid taking it with strong CYP3A4 inducers such as rifampin, carbamazepine, phenytoin, or St. John’s wort as they can reduce its effectiveness. Also avoid use in people with a history of QT prolongation, low potassium, or low magnesium, or those taking other drugs that affect the heart rhythm. Do not take halofantrine within one month of using Udother.

Frequently asked questions

What is Udother used for?

Udother is used to treat acute, uncomplicated malaria caused by the Plasmodium falciparum parasite in adults and children weighing at least 5 kg.

What are the side effects of Udother?

Common side effects include headache, loss of appetite, dizziness, weakness, and joint pain. Serious side effects like allergic reactions or heart rhythm problems are rare.

Can I buy Udother without a prescription in Nigeria?

Yes, Udother is available over the counter (OTC) in Nigeria. You can order it directly from Drugstore.ng without a prescription.

How is Udother taken?

Udother is taken with food over 3 days: an initial dose, a second dose after 8 hours, then twice-daily (morning and evening) for the next 2 days. The exact dose depends on your weight.

Who should not take Udother?

Do not take it if you are allergic to artemether or lumefantrine, or if you are taking certain medicines like rifampin, carbamazepine, phenytoin, or St. John’s wort. People with heart rhythm problems should use it with caution.

This information is for general guidance only and is not medical advice. Please consult your physician or pharmacist before using any medication.

Take Udother with food or a milky drink. The full course is given over 3 days, totaling 6 doses. Typically, the first dose is taken, then a second dose 8 hours later, followed by twice-daily (morning and evening) for the next 2 days. For adults weighing 35 kg or more, the typical dose is 4 tablets each time. Always follow your doctor’s instructions exactly as the dose depends on your weight and age.
Do not use Udother if you are allergic to artemether or lumefantrine. Avoid taking it with strong CYP3A4 inducers such as rifampin, carbamazepine, phenytoin, or St. John’s wort as they can reduce its effectiveness. Also avoid use in people with a history of QT prolongation, low potassium, or low magnesium, or those taking other drugs that affect the heart rhythm. Do not take halofantrine within one month of using Udother.

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