Lamivudine/Nevirapine/Zidovudine 30 mg/50 mg/60 mg Dispersible Tablets

This combination tablet contains nevirapine and other antiretroviral medicines. It is used for the treatment of HIV-1 infection in adults and children aged 6 years and older, when taken together with other antiretroviral agents.

What it is

It is an antiretroviral medicine that includes nevirapine. Nevirapine is part of a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). This product is a fixed-dose combination tablet designed to be dispersed in water before taking.

What it's used for

This product is used to treat HIV-1 infection in adults and children 6 years of age or older with a body surface area of 1.17 m² or greater. It must be taken in combination with other antiretroviral medicines. There are special limitations: it is not recommended to start treatment with nevirapine in adult females with high CD4+ cell counts (except when the benefit outweighs the risk) due to a risk of severe liver problems.

Common side effects

The most common side effect is rash. In adult studies, about 3% of people developed a moderate to severe rash during the first two weeks, and another 3% after switching to the extended-release tablet. Other side effects can include liver inflammation (hepatitis). If you develop a rash with fever, blisters, or mouth sores, contact your doctor immediately.

Important cautions

This medicine should not be used in patients with moderate or severe liver disease (Child-Pugh class B or C). It is also not recommended for post-exposure prophylaxis (prevention after potential exposure to HIV). Rare but serious liver damage, including liver failure, has been reported, especially in the first 6 weeks of therapy. Your doctor will monitor your liver function. Tell your doctor if you have a history of liver problems, hepatitis, or if you are pregnant or breastfeeding. Watch for signs of immune reconstitution syndrome (unusual infections or inflammatory symptoms) and fat redistribution (changes in body fat).

Frequently asked questions

What is this medicine used for?

It is used to treat HIV-1 infection in adults and children aged 6 years and older. It is always used together with other antiretroviral medicines.

Can I buy it without a prescription in Nigeria?

Yes, this product is classified as an over-the-counter (OTC) medicine. However, HIV treatment requires medical supervision, so you should consult a doctor before starting any antiretroviral therapy.

What are the common side effects?

The most common side effect is rash. Other possible side effects include liver inflammation, nausea, and changes in body fat distribution. Call your doctor if you develop a severe rash, jaundice, or signs of liver problems.

How should I take this tablet?

The tablet is for oral use and must be taken exactly as your doctor directs. In clinical studies, nevirapine was started with a 14-day lead-in dose of a different form to reduce rash risk, then switched to the once-daily form. Do not chew or crush the tablet.

Are there any serious warnings?

Yes. This medicine can cause severe liver damage, especially in the first 6 weeks. It must not be used if you have moderate or severe liver disease. It is also not for use after a potential HIV exposure. Your doctor will run regular blood tests to check your liver.

This information is for general guidance only and is not medical advice. Please consult your physician or pharmacist before using any medication.