Co-Aprovel 300 mg/25 mg Tablets (Irbesartan; Hydrochlorothiazide)


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Co-Aprovel is a thiazide diuretic tablet used for high blood pressure and fluid retention. It helps remove excess water and salt from the body.

What it is

Co-Aprovel contains hydrochlorothiazide, a thiazide diuretic medicine. It works by increasing urine output to reduce fluid retention and lower blood pressure.

What it's used for

It is used to treat oedema (fluid retention) caused by conditions like heart failure, liver cirrhosis, kidney disease, or corticosteroid/estrogen therapy. It is also used alone or with other medicines to manage high blood pressure.

Common side effects

Common side effects include weakness, low blood pressure (especially on standing), nausea, vomiting, diarrhoea, constipation, stomach cramps, and loss of appetite. Rare but serious side effects include blood disorders, liver problems, and allergic reactions.

Important cautions

Do not use this medicine if you cannot pass urine (anuria) or are allergic to hydrochlorothiazide or sulfonamide drugs. Use with caution if you have severe kidney or liver disease. It may worsen electrolyte imbalances. Tell your doctor about all other medicines you take.

Frequently asked questions

What is Co-Aprovel used for?

Co-Aprovel is used to treat high blood pressure and fluid retention (oedema) caused by heart, liver, or kidney problems.

Can I buy Co-Aprovel without a prescription in Nigeria?

Yes, according to available information, Co-Aprovel is an over-the-counter medicine in Nigeria. However, always consult a pharmacist or doctor before use.

What are the side effects of Co-Aprovel?

Common side effects include weakness, low blood pressure, nausea, diarrhoea, and stomach upset. Serious side effects such as blood disorders or allergic reactions are rare.

How should I take Co-Aprovel?

Take Co-Aprovel exactly as prescribed by your doctor. It is usually taken by mouth once or twice daily. Your doctor may adjust the dose based on your condition.

Can Co-Aprovel be taken during pregnancy?

Routine use of diuretics like hydrochlorothiazide during normal pregnancy is not recommended. Consult your doctor for individual advice.

This information is for general guidance only and is not medical advice. Please consult your physician or pharmacist before using any medication.

The dose is individualised by your doctor. It is usually taken by mouth once or twice daily. For oedema, some people take it on alternate days. Always follow your doctor’s instructions exactly.
Do not use this medicine if you cannot pass urine (anuria) or are allergic to hydrochlorothiazide or sulfonamide drugs. Use with caution if you have severe kidney or liver disease. It may worsen electrolyte imbalances. Tell your doctor about all other medicines you take.

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